British Air Force Typhoon fighter aircraft have operated alongside French aircraft in a coordinated attack targeting an underground arms cache in Syrian territory used by the IS group, per a report from the UK's MoD.
The location, located using reconnaissance, was believed to be housing weapons and explosive materials, the statement said, and was positioned in hills just above Palmyra in Syria's central region.
"Our aircraft employed precision-guided Paveway IV munitions to strike a number of approach shafts down to the depot... initial indications are that the objective was successfully hit," the ministry announced.
There was no indication of any civilian casualties in the operation late on Saturday and all the aircraft made a safe return, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
Daesh - alternatively referred to as the so-called Islamic State - established militant control over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This strike underscores the UK's leading role, and commitment to operate in unison with allied nations, to eradicate any re-emergence of the terrorist group and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief John Healey stated.
UK warplanes have performed patrols over Syrian airspace to "forestall any attempted comeback" of the group subsequent to its routing at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to the personnel of British forces involved in this strike for their skill and their valour," he added. "Including them were a great many British personnel stationed over the holidays. This operation, to remove militants who pose a risk to our security, shows how British military are prepared to act, all year round, protecting the UK domestically and influential overseas."
In December, the American forces conducted what it termed a "large-scale strike" against IS targets in Syria, after an ambush resulted in the deaths of two US troops and a civilian interpreter in Palmyra.
The U.N. says IS still maintains an estimated 5,000 to 7,000 combatants in Syria and Iraq.